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Ep. 277: Epigenetics, Adoption, and Turning Genes On and Off

In this episode, Stacy and Sarah talk about epigenetics and how gene expression can be affected by different lifestyle stresses and factors.

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If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 277: Epigenetics, Adoption, and Turning Genes On and Off

  • News and Views (0:41)

    • This is a topic that made Sarah really excited! This is fascinating science stuff!
    • Last year, Stacy's mom, who is adopted, tracked down her family using genetic tests from 23andMe and Ancestry.com
    • She found her father, two full sisters and four half siblings! So crazy!
    • Unfortunately, Stacy and her mom also found that cancer runs very prevalent in her family.
    • And Stacy's mom found that her full sisters were really similar to her, even in minor things like interests and hobbies and laughter.
    • Stacy was fascinated by this article about epigenetics and adoption and gave it to Sarah.
    • Epigenetics is the system where the body turns on or off or alters genes without actually changing DNA. There are a variety of ways that this can happen like stress, trauma, lifestyle, diet, environment, etc. And it's also heritable.
    • Discover magazine article: "Grandma's Experiences Leave a Mark on Your Genes"
    • These epigenetic signals control a variety of things like inflammation, insulin sensitivity, neurotransmitter regulation.
    • The emotional experiences around adoption can cause epigenetic changes in the brain.
    • Discovery came out of experiments on nature vs. nuture. They found that rats that were groomed more by their mothers were more resilient to stress. But then they found that this was caused by epigenetic changes in cortisol pathways. They then tested the theory by switching mothers and found that the epigenetics changed for the inattentive mothers' babies.
    • It's not nature vs. nuture; It's nature affects nuture affects nature!
    • The theory goes now that the stress of being adopted affects epigenetics, but the new nuturing environment could reverse any damage. Adoptive parents would best be served by taking that into account and be sure of providing nuturing touch and love.
    • Thousands of epigenetic changes are made in childhood that could affect the adult life
    • Some companies are working on developing a epigenetic "clean slate" to reset epigenetic markers for people adversely affected by epigenetic problems.
    • This might be harmful for some, but also could help people affected by depression, addiction, phobias and other severe challenges.
    • Epigenetic changes could affect three generations thanks to epigenetics: stress to the mother affects the fetus, who's eggs are also developing, affecting the grandchild!
    • Evolutionarily, these epigenetic changes make sense: they provide very quick change to genetic presentation without waiting generations for natural selection to select.
    • We know that certain things are bad for epigenetic control: overeating, nutrient deficiency, stress, famine, etc.
    • Stacy has noticed that snuggling her children is very good for them and her.
    • The three generation inheritance means that grandchildren of holocaust survivors are still affected by the holocaust!
    • They have found that it is definitely in childhood that makes the most epigenetic difference: you are much more affected by poor socioeconomic status in childhood than adulthood, for example.
    • Some epigenetic controls are inherited, but some are wiped clean between generations.
    • Sarah's NOVA special on Epigenetics.
    • Two types of chemicals are epigenetic controls: Methyl groups turn off genes, Acetyl groups turn them on. So how is this affected in people with MTHFR mutations?
    • This whole field of study is going to be explored more and more in the coming years and we'll know so much more about how to control all this stuff!
    • Stacy is often wondering how her lifestyle might have affected Cole when she was pregnant with him during a more chaotic time in her life.
    • Sarah says these discoveries are evidence that we need to FUND MORE BASIC SCIENCE EXPLORATION!
  • Next week: An exciting guest!
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  • Outro (52:06)

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Ep. 276: Combining AIP with Other Diet Protocols

In this episode, Stacy and Sarah answer a common question: can I combine the Autoimmune Protocol with other diets and protocols like keto and intermittent fasting?

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If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 276: Combining AIP with Other Diet Protocols

  • News and Views (0:41)

  • Meredith asks (13:04), "Hi Dr. Ballantyne! I found one of your articles on intermittent fasting and the autoimmune protocol. It indicates that we should not do both as the same time due to putting too much stress on the body. However, do you think that's it okay to do both if I have already been on IF and Keto for at least 3 months prior to starting AIP?"
    • We have done shows on Keto and our opinions of it. Hint: not fans. Start there for more!
    • The AIP is supposed to be a nutrient dense diet and Keto and IF will make it hard to impossible to get the nutrient density! You'll lose the most important part of AIP!
    • Many people who go too low carb end up making their conditions WORSE! Stacy experienced this.
    • AIP removes inflammatory foods, adds nutrient sufficiency and lifestyle factors and ends up being great for immune, endocrine and all over health. It, by itself, should resolve most conditions you might be using Keto and IF for.
    • The only things Sarah could conceive of using with AIP, would be a short term low FODMAP diet for SIBO, but typically you can't resolve SIBO with diet alone.
    • Even then, don't do any other diets without the supervision of a health professional
    • Even GAPS and SCD, which are recommended for gut health, the AIP is already designed to help gut health!
    • Fasting is recommended for the "spring clean up" effect of autophagy. But autophagy is also a part of sleep and exercise! So you shouldn't need IF
    • And women especially don't get the benefits because their hormones are usually much more susceptible to making up the loss of calories with hunger.
    • Keto was originally for people who had epilepsy because it usually reduced the number of seizures by simulating starvation.
    • But women tend to lose their periods and fertility on Keto. Not good!
    • Keto does supress the immune system. So you might see relief from inflammation, but over time you become susceptible to infections. It's not regulated, it's just supressed!
    • Keto also harms your gut friends, too. Your favorite friends need carbs and fiber! This leads to poor digestion plus mood effects and lots of other problems.
    • Keto may cause the same IRREVERSIBLE effects to your gut microbiome as antibiotics!
    • But really, listen to your body. If you're looking for something to add to Keto and IF, then maybe they aren't working for you and you should give them up.
  • Next week is going to be a great show about a story Stacy's been sitting on for a while!
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  • Outro (37:16)

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Ep. 275: Cancer Risk from Personal Care Items

 

In this episode, Stacy and Sarah are talking about the hazardous components of a lot of personal care items.

Click here to listen in iTunes

or download and listen by clicking the PodBean Player below

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 275: Cancer Risk from Personal Care Items

  • News and Views (0:41)

    • This episode is inspired by Stacy's post on Federal Regulations
    • Sarah also read State of the Evidence 2017 from the NIH
    • We are constantly bombarded by toxic compounds that are everywhere in the environment and can lead to bad health conditions!
    • But if you're feeling overwhelmed, remember the protective effects of veggies, nutrient sufficiency and sleep.
    • Check out the EWG app to scan items to find how toxic items you use are.
    • The NIH paper went over the evidence of breast cancer to determine why the rates are increasing.
    • These chemicals are not just about breast cancer, but can cause all kinds of chronic disease.
    • Hormone disruption is one of the key reasons. Extra estrogen can cause breast cancer. For example, hormone replacement and birth control
    • You will find issues in hormonal products as well a disrupters like BPA in plastics.
    • Stacy likes Beautycounter products
    • Sarah uses Buffalo Gal and Primal Life Organics.
  • Rate and review us. Goodbye!
  • Outro (23:20)

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Ep. 274: Sarah Hugs Our Listeners

 

In this episode, Sarah is on the road for her Paleo Principles tour! We welcome Paleo Principles into the world!

Click here to listen in iTunes

or download and listen by clicking the PodBean Player below

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 274: Sarah Hugs Our Listeners

  • News and Views (0:41)

    • Paleo Principles is out now! Sarah is extremely proud of this veritable text book of paleo science with a recipe book to boot.
    • Sarah is now out on tour, hugging everyone and enjoying meeting our listeners.
    • This is one of the best things about t0urs: meeting you!
  • Rate and review us. Goodbye!
  • Outro (23:20)

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Ep. 273: Paleo Principles Debuts!

 

 

In this episode, Sarah is on the road for her Paleo Principles tour! We welcome Paleo Principles into the world!

Click here to listen in iTunes

or download and listen by clicking the PodBean Player below

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 273: Paleo Principles Debuts!

  • News and Views (0:41)

    • Paleo Principles is out now! Sarah is extremely proud of this veritable text book of paleo science with a recipe book to boot.
    • And she is on tour now, ready to deal hugs and laughs and answer your questions. Go here to see where she's going and RSVP!
    • Stacy is into this book too. The graphics, the breakdowns, the recipes. Oven cooked scrambled eggs!
  • Rate and review us. Goodbye!
  • Outro (41:10)

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Ep. 272: What's the Deal with Essential Oils?

 

In this episode, Stacy and Sarah wade into essential oils and parse out what the risks and what the benefits of using them might be.

Click here to listen in iTunes

 

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 272: What's the Deal with Essential Oils?

  • News and Views (0:41)

  • Meanwhile, Stacy bought Essential Oils. She couldn't wait for Sarah's research.
    • She's using them in oil diffusers to make her boy and lizard smelling house smell better without using toxic fragrances.
    • But she needs to know if they help people, if they're toxic and if they kill cats
  • Sarah's links on Essential Oil scientific research!
  • Sarah's research!
    • First of all, divide essentially uses in two ways: use as aromatherapy and use topically or orally.
    • Essentially oils are volatile compounds (they reacted easily with the environment), complex components and usually have a strong odor extracted from botanicals.
    • Extracted by steaming them out or pressing out, not solvent extraction
    • Over 3000 essential oils are out there, and each one has 20-60 chemicals that make it up. Among those, 2-5 are the dominant, key compounds.
    • Scientific research seems to indicate the synergy of all the compounds may be key to the effects of essential oils, not just the presence of the key compounds.
    • Key compounds: triterpenes, aldehydes, alcohols, ketones, ethers, oxides, esters, amines, amides, phenols, heterocycles, other terpenes. All small molecules, and thousands have been found in essential oils.
    • These are phytochemicals and can be anti-inflammatory, immunomodulatory, anti-angiogenic (prevent the formation of blood vessels, great for fighting tumors), apoptosis (helps cells dies), anti-allergy, anti-mutagenic, anti-microbial, insect repellents, etc. They are an interesting avenue for research for many reasons. Antibiotics, disinfectants, cancer drugs, food preservation
    • There are tables and tables of essential oils and what microbes they can kill.
    • But they are cytotoxic: they rupture membranes and cause cells to die. So they ARE NOT SPECIFIC to bad microbes! They'll kill your friends in your gut! NOT GOOD!
    • Meanwhile, terpenes are damaging to the liver. That's also NOT GOOD!
    • They may also cause a leaky gut.
    • Drinking essentially oils is probably not a great idea without a doctor's recommendation.
    • There are some essential oil compounds that are more specific, though, methylenonylketone compound is effective to kill influenza. Others have been shown to kill E. coli, Staphylococcus, etc. But some kill the good'uns. Eucalyptus is good for staph, pneumonia, strep, enterobacter, but also, lacto bacilus, bacilus cereus, and other probiotics.
    • Probably not a problem for aromatherapy, but ingesting is complicated! We don't know everything that these properties do!
    • Some have good anti-inflammatory properties: tea tree oil, clove oil, parsley oil, lemongrass oil, metharvensis oil
    • How do you find what an essential oil does and what warnings there are? NAHA and FDA have information about what has been deemed safe (and most have) but Sarah goes to PubMed to research directly. She doesn't think there's much reason to ever ingest essential oils.
    • Many studies are done on cultured cells and on rodents, not necessarily a direct comparison to what would happen to a person.
    • But if you want these effects, just eat the whole food! This will protect you much better than the concentrated form.
  • But what about the cats!?
    • There have been no studies of cats and essential oils. All evidence is anecdotal, but that doesn't mean it's not true. Though cats livers aren't as robust at taking care of toxins as people and dogs.
    • Stacy isn't using them all the time, only using them in certain rooms, and allowing the cats to escape if they want to.
  • Overall, what is the deal?
    • The science is complicated. There are many interesting studies, but lots of pros and cons.
    • With over 3000 different oils, its hard to narrow it down and know everything about it.
    • Aromatherapy is probably safe, safer than oral consumption for sure!
    • Only use oral consumption with the supervision of a doctor who knows what they are doing.
    • The science is not very strong for most purported benefits. Most papers indicate that we need more research. But, really, if its from an edible thing that you want the benefits from, just eat the thing.
    • Sarah says to go to pub med for information on each ingredient and make your own decisions.
  • Rate and review us. Goodbye!
  • Outro (1:03:09)

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Ep. 271: Chris Kresser Practices Unconventional Medicine

 

In this episode, we talk to Chris Kresser about how to make healthcare more practical, sustainable, and better at treating chronic disease.

Click here to listen in iTunes

 

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 271: Chris Kresser Practices Unconventional Medicine

  • News and Views (0:41)

    • Our guest today is Chris Kresser! He's a practicing functional medicine doctor, blogger, author and "voice of reason" we really admire.
    • He was a guest on Episode 86 as well.
    • Chris's new book is about changing how we approach healthcare. It's titled Unconventional Medicine and comes out November 7th
    • Stacy discovered Chris Kresser through Robb Wolf's podcast where he challenged Robb Wolf on Fish Oil. It was refreshing to see two thought leaders debating a topic and one change his mind.
    • Chris's old book was called The Paleo Cure.
    • Chris was interested in how he could change health care practices through his own work in his clinic.
    • Conventional medicine doesn't treat chronic disease very well and it could be disastrous for the economy of the United States.
    • Doctors give the recommendation of "eat better, exercise" but don't really give details, follow up, or help you get there.
    • Chris got very sick from parasite infections in his early 20s and while he recovered from the acute infection easily, the chronic remnants of the disease continued until he figured out how to heal himself.
    • Functional medicine is a systems biology approach to medicine.
    • Chris's analogy: If you have a rock in your shoe, conventional medicine diagnoses you with foot pain and gives you a tylenol. Functional medicine tells you to dump out the rock.
    • People are on all kinds of medicine when better approaches might lead to fewer. Instead of suppressing systems, Functional medicine tackles the causes of disease, especially diet and lifestyle factors.
    • Stacy recently had an experience with a regular doctor that made her wonder if patients are part of the problem: they want a pill to fix it rather than working on their diet and lifestyle.
    • Chris's practice follows up and provides resources to help patients do it.
    • One in Two people has chronic disease and one in four have multiple chronic disease. We have to reverse this!
    • Meanwhile, Sarah is very concerned that she wasn't getting enough interventions with conventional medicine.
    • Chris says doctors are upset with modern medicine as well. They're burned out, don't have enough time, and half want to quit!
    • Doctors are being pushed too hard. They see twice as many patients as they did a few decades ago.
    • Chris envisions a system where someone who comes in with pre-diabetes is assigned a nutritionist and a personal trainer and a gym membership rather than pills and no follow up. He sees this as cost effective: $1 million over the course of a lifetime vs. $10000
    • Chris sees this as a virtuous cycle rather than a vicious cycle. Things actually get better over time.
    • We spend 3.2 trillion dollars per year on healthcare. That's $10000 per person, or 1/3 of the median income.
    • We need to stop accepting chronic illness as normal. It's not normal, its common. As Angelo Coppola says, "Humans are not broken by default."
    • The health insurance model has only been around for 60 years or so and people paid for their own. This kept costs down.
    • Catastrophic Care gives the example of people giving the options of either taking statins covered by insurance or paying on their own to change diet and lifestyle and exercising. These are not equivalent choices and few would not choose the "free" pill option.
  • Rate and review us. Goodbye!
  • Outro (1:01:21)

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Ep. 270: Lady Gaga and Taking Care of Yourself

 

 

In this episode, Stacy and Sarah talk about Lady Gaga and her health issues and how we can learn from her hectic lifestyle potentially causing her trouble.

Click here to listen in iTunes

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 270: Lady Gaga and Taking Care of Yourself

  • News and Views (0:41)

    • We have put out one episode every week for 270 weeks in a row!
    • This week's episode is about Lady Gaga on her new Netflix special Gaga: Five Foot Two (Warning for boobs)
    • Gaga has had autoimmune diseases, Fibromyalgia that have affected her touring and health.
    • She could get up for her shows with the adrenaline rush, but her health was always declining.
    • She also said her thyroid medication was "unrelated" to her health issues (but it's probably not!)
    • There have been rumors floating about concerning her maybe being paleo. She uses words that are adjacent to paleo without ever saying paleo.
    • (By the way, Sarah is totally like Lady Gaga.)
    • Sarah relates because she is also constantly derailed by lifestyle factors.
    • You need to keep up with health and activity and stress to keep yourself healthy! But we always convince ourselves they aren't important! Diet is much easier than slowing yourself down.
    • Reaching for crutches (alcohol, cigarettes, drugs, other comforts) is often seen when your lifestyle isn't in order.
    • It's important to listen to your body throughout the day, not just on the highs where you feel great.
    • Sarah handles this by setting up rules for herself: she has a bedtime, she caters her dedicated exercise schedules to how she's feeling, and focuses on diet when her stress is high, and cuts back on activities she agrees to when she's stressed.
    • Putting out health issues is better for the public understanding of them. It reminds Stacy of Selena Gomez having a kidney transplant this summer. Use celebrities to talk health with your loved ones.
    • Autoimmune diseases are isolation so seeing a public figure suffering makes people feel better.
    • See thepaleomom.com/events to see when Sarah will be at a town near you. RSVP NOW!
  • Rate and review us. Goodbye!
  • Outro (53:09)

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Ep. 269: What Is a Real Detox and What Is Bunk?

In this episode, we discuss the difference between trendy detoxes and helpful ones and explain how your body really detoxes.

Click here to listen in iTunes

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 269: What Is a Real Detox and What Is Bunk?

  • News and Views (0:41)

    • Sarah and Stacy are recording during the day, and Sarah isn't in her PJ's (for once!)
    • Sarah's still tired because she's been recording videos for the Autoimmune Protocol Lecture Series videos all week.
    • Stacy is excited about the next few shows because she got to pick the topics!
    • After finishing Paleo Principles (which is 672 pages) Sarah went right into filming videos.
    • Her feet have been swelling at night with no real explanation, and this got worse during filming.
    • Sarah's FIFTH formulation of her thyroid medication has been working really well, and she is happy that she's lost some weight as a side effect.
    • Stacy says that Sarah is a good example of weight loss coming on the heels of improved health. But it might also be triggering her swollen feet...
  • The Truth About Detoxes
    • This week's episode is Stacy's suggestion, but it comes at a great time because of Sarah's swollen feet!
    • Sarah's Functional Medicine specialist suggested that estrogen stored in her fat, which was released during her rapid fat loss, might be causing the swelling in her feet.
    • So, her doctor recommended a medical detox from Douglas Labs, which helped reduce the swelling right away!
    • Stacy thinks there's a lack of education around other types of detoxes, as well as marketers who prey on "detox" searches on the web.
    • Sarah says lots of detoxes have no grounding in science; a lot of them are fiber-rich and make you poop a lot. Another example is the coffee enema, which can actually be dangerous. Read Sarah's post "Coffee Enemas: What the Science Says versus What You've Heard" for more.
    • Interestingly, lots of detoxes, like juice cleanses, can have immediate beneficial effects because you're eating more veggies and pulling out inflammatory foods (such as FODMAP's and alcohol). However, they're not a good solution because they starve your beneficial gut bacteria.
    • Detoxification happens in the liver, but these cleanses don't support the liver.
    • Most "Toxins" are fat-soluble, including heavy metals, metabolic by-products, and excess hormones.
    • Liver detox:
      • Phase 1: Liver transforms them into water-soluble forms.

        • Nutrients for this include B Vitamins, Vitamin A, Magnesium, Zinc, Selenium.
      • Phase 2: Conjugation - the water-soluble molecule is combined with something to neutralize it, and by-products are secreted into small intestine and eliminated or sent to kidneys and eliminated
        • Nutrients for this include Amino Acids, Glutamine, Methionine, Taurine, Cysteine, Vitamin B and C, Selenium.
    • Liver stores the nutrients needed for detoxification, so eating liver (or taking Vital Proteins Liver Pills) is a great "detox" strategy.
    • Fiber from veggies (especially non-starchy), water, organ meats, bone broth, seafood, and fruit are all great detox foods - i.e. the Paleo diet!
    • It's also important to stay hydrated.
    • If your liver can't keep up, supporting Phase 1 or Phase 2 with botanicals like Milk Thistle can be helpful.
    • This is what a medical detox looks like; it should only be done under a doctor's supervision.
    • In contrast, most detoxes just clear out your good bacteria and don't support your liver at all.
    • Stacy really doesn't like that companies use misleading "marketing techniques" to convince people to buy their detox products that don't work.
    • Find a good functional medicine doctor to work with!
    • Stacy and Sarah both love Vital Proteins beef liver pills.
  • Rate and review us. Goodbye!
  • Outro (53:09)

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Ep. 268: How Do I Know if My Gut is Healthy?

In this episode, Stacy and Sarah talk poop! They discuss how you can tell if your digestion is in shape and what to do if it's not.

Click here to listen in iTunes

If you enjoy the show, please review it in iTunes!

The Paleo View (TPV), Episode 268: How Do I Know if My Gut is Healthy?

  • Intro (0:00)
  • News and Views (0:41)
    • The phrase is: "Trying to get credit for things you're supposed to do." It was inspired by a profane Chris Rock bit from Bigger and Blacker.
    • Stacy has become a big fan of Felix Gray computer glasses! They are awesome!
    • This week our topic is all about gut health! Stacy is SO into it!
    • We have a lot of questions about it, probably because the topic is so taboo in polite society.
  • Genia says, "How do you tell if you have an unhealthy gut? What are the best things I can start doing now to start working on my gut health? I am very new to paleo and there is a lot of info out there. Thank you for any info or tips. Also I am slowly listening to your past podcast. What do you think are the best episodes for a newbie to listen to first?" (8:26)
    • Don't listen to our first Mark Sisson episode where Sarah fangirled all over him. (Do listen to that!)
    • What Do I Do After a Bad Reaction
    • Stefani Ruper's shows are Episode 80, Episode 87, Episode 6, and Strong Woman Radio 25
    • Denise Minger is here and here
    • And check out our Paleo 101 series here.
    • At home gut health tests are in Paleo Principles and on The Paleo Mom.
    • Gastrointestinal symptom checklist:
      • gas
      • bloating
      • bleching
      • constipation
      • diarrhea
      • heartburn
      • indigestion
      • pain or straining
      • undigested food
      • mucus
      • blood in the stool (dark clotted blood. bright blood is from anal fissures probably)
    • If you notice your digestion, there's probably something wrong.
    • Normal frequency is 3 times per day to 3 times per week.
    • Sarah is a fan of Dr. Jeff Leach from the Human Food Project.
    • Stacy reminds herself that only humans are embarassed by poop this way.
    • Compare your poop to the Bristol Stool Scale. You should consistently at level 3 or 4.
    • Transit time test: eat something you can see in your stool like corn or sesame seeds or beets. Time from eating to pooping. Ideally between 12-48 hours.
    • If your concerned, see a doctor. They can do more tests like stool analysis, colonoscopy, biopsy, etc.
    • If you don't need a doctor's care, then you probably need to change your diet.
      • Increase fruits and vegetables. It's the fiber.
      • Increase Omega-3 fat intake.
      • Lower saturated fat
      • Eating fermented foods, especially wild fermented.
      • Some nutrients help form the intestinal junctions: fiber, quercitin, burburein, zinc, and glycine.
    • Don't get overwhelmed by feeling like you need to do everything at once! Take it steps at a time.
    • Focus on nutrient density and everything else can follow. Is this food helping my health, hurting my health or neutral?
    • DO NOT SEND US PICTURES OF YOUR POOP!
  • Rate and review us. Goodbye!
  • Outro (46:45)

 

 

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